This volume is divided into two sections focusing on immunity and infection. Each chapter explores a rapidly evolving area of clinical science and aims to highlight not only current areas of acute research interest, but how the specific basic science connects to the patient.
Minimally Invasive Breast Biopsies, 2009
(Recent Results in Cancer Research)
Renzo Brun del Re
Modern imaging methods have made it possible to detect breast cancer at an earlier stage than in the past. Nevertheless, a large majority of suspicious findings at screening subsequently prove to be benign. It is therefore important to be able to identify benign lesions in a manner that is reliable, tissue sparing, patient friendly, and cost-effective. More than 70% of breast biopsies can now be performed using minimally invasive procedures that meet these criteria. This book examines in detail vacuum-assisted minimally invasive breast biopsy systems (ATEC, EnCor, Intact, Mammotome and Vacora), stereotactic systems, MRI-guided procedures, and ductoscopy. Further chapters are devoted to the pathology of the breast tissue obtained using these procedures, their limitations, the implications of recent advances in breast imaging, and the results of cost-benefit analyses. The closing chapter provides a systematic review and meta-analysis of recent data.
This edition of Essentials of Rubin's Pathology recognizes the expansion of knowledge relevant to pathology into the molecular realm and contains a considerable amount of new material. It should continue to serve the needs of all students of pathology who wish to integrate the concepts of molecular, cellular and tissue based biology with the study of clinical medicine.
free download in single pdf file [ 45 MB ]
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Ophthalmic Pathology: an illustrated Guide for Clinicians, 1st ed,
K. Weng Sehu, William R. Lee
ISBN-13: 978 0 727917 79 9
ISBN-10: 0 727917 79 X
Blackwell Publishing Ltd, BMJ Books
This outstanding atlas of ophthalmic pathology brings together the world famous collection of digital images from the Tennant Eye Institute in Glasgow.
Weng Sehu and William Lee have produced a unique body of information, moulding Ophthalmic Pathology and the accompanying interactive CD-Rom into the essential ‘must-have’ revision aid and reference book for ophthalmologists in training, teachers and clinical ophthalmologists worldwide.
Ophthalmic Pathology is a concise, yet informative, user friendly textbook whose unparalleled image collection will more than meet the expectations of the ophthalmological community.
This new edition of Medical Immunology has been thoroughly revised and reorganized. The book starts with basic immunology followed by diagnostic immunology. Author give special attention to diagnostic immunology.
Review of Medical Microbiology & Immunology, 10th Ed, 2008
The McGraw-Hill Companies, Inc.
This book is a concise review of the medically important aspects of microbiology. It covers both the basic and clinical aspects of bacteriology, virology, mycology, parasitology, and immunology. Its two major aims are (1) to assist those who are preparing for the USMLE (National Boards) and (2) to provide students who are currently taking medical microbiology courses with a brief and up-to-date source of information.
Physician’s Guide to the Laboratory Diagnosis of Metabolic Diseases,
N. Blau, M. Duran, M. E. Blaskovics, K . M . Gibson
ISBN: 354042542- X
This book presents the signs and symptoms of most of the recognized inborn errors of metabolism in relation to age. There is a chronological sequence of signs and symptoms from infancy through childhood , adolescence and adulthood, and in addition, normal and pathological values are provided for each of the disorders so that one does not have to wonder about the significance of laboratory tests and reported values.
Diagnostic Histopathology of Tumors, 3rd ed, CD-ROM
Christopher D. M. Fletcher
■Features over 3,000 high-quality full-color illustrations, providing visual guidance to each tumor or tumor-like entity.
■Presents correlations of gross appearances to microscopic findings for virtually every tumor type.
■Includes detailed discussions of differential diagnosis.
■Provides full coverage of all the latest classification schemes.
These are the ONLY CD-ROMs of "Diagnostic Histopathology of Tumors" for free download.
Part One: Platelet Biology
Part Two: Tests of Platelet Function
Part Three: The Role of Platelets in Disease
Part Four: Disorders of Platelet Number and Function
Part Five: Pharmacology: Antiplatelet Therapy
Part Six: Pharmacology: Therapy to Increase Platelet Numbers and/or Function
Part Seven: Platelet Transfusion Medicine
Part Eight: Gene Therapy for Platelet Disorders
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Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook
Paolo Gresele, Valentin Fuster, Jose A. Lopez, Clive P. Page, Jos Vermylen
ISBN-10 : 0521881153
ISBN-13 : 9780521881159
Cambridge University Press
Thebookhasbeenorganizedintofoursections,covering platelet physiology, bleeding disorders, thrombotic disorders, and antithrombotic therapy. A total of 26 chapters cover all the conventional and less conventional aspects of platelet involvement in disease; emphasis has been given to the recent developments in each ﬁeld, but always mentioning the key discoveries that have contributed to present knowledge.
Platelets and Megakaryocytes, Vol-1 Functional Assays, 2004
(Methods in Molecular Biology, Vol-272)
Jonathan M. Gibbins, Martyn P. Mahaut-Smith
Volume 1 provides details basic and advanced techniques for analyzing platelet and megakaryocyte function. The approaches presented for platelet analysis include aggregometry, secretion, arachidonic acid metabolism, procoagulent response, platelet adhesion under static and flow conditions, flow cytometry, and production of microparticles.
Platelets and Megakaryocytes: Vol-2, Perspectives and Techniques
(Methods in Molecular Biology Vol-273)
Jonathan M. Gibbins, Martyn P. Mahaut-Smith
Volume 2 offers techniques for studying many aspects of signaling in platelets and megakaryocytes, as well as state-of-the-art commentaries on our understanding of these cells. The methods include ligand-binding assays, the study of protein and lipid kinases and phosphatases, the analysis of lipid rafts, and the measurement of intracellular calcium levels. There are also techniques for study of electrophysiological events, nitric oxide signaling, venom proteins, and for the internalization of proteins into platelets through permeabilization.
The histological descriptions continue to be liberally illustrated with photomicrographs. In keeping with current practice and taking advantage of modern technology, the figures in this edition are mostly presented in color.
Part-I of the book concentrates on the preparation of tissue, providing an overview of fixation, embedding, and processing (Chapter 1), and in Chapters 2 and 3, the required techniques for the retrieval of RNA from histological sections. Both routine and specialist histological staining techniques are provided in Part-II. These include proto- cols for immuno (Chapters 4–7), lectin (Chapter 8), and hybridization (Chapter 9) histochemistry, histological staining (Chapters10and 11), as well as specific methods for the in situ identification of hypoxia (Chapter 12) and apoptosis (Chapter 13). Finally, Part-III details advances in imaging (Chapters 14–16) and image analysis (Chapter 17).
This book is divided in two parts that comprise a total of 16 chapters, each of which can be read independent of the rest. The first part consists of five chapters, three of which discuss aspects of bacterial pathogenesis that are common to all pathogens: evolution, secretion, and regulation of virulence determinants. The fourth chapter presents a thorough description of the strategies currently used to identify virulence determinants. The fifth chapter discusses bacterial pathogens of plants, highlighting the similar mechanisms that bacterial pathogens of animal and plants employ when interacting with their respective hosts. These first 5 chapters serve as a general introduction to the 11 pathogen-based chapters that comprise the second part of the book.
Chronic Myeloid Leukemia (CML) remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level and has been used by researchers to develop a variety of therapies and therapeutic assessment methods. This concise, readable guide assembles and synthesizes the latest developments and trends in the treatment of CML and provides an authoritative and convenient summary of the latest progress in imatinib trials, the molecular monitoring of CML responses, and the engineering of new therapies to overcome resistance and improve patient care.
Providing critical insight and exploration of models that will enhance the cancer community at large, this source:
stands as the only source to focus on post-Gleevec developments in CML therapeutics
collects information from the forefront of the field—helping busy clinicians make informed management decisions
supplies critical research from recognized opinion leaders on the topic
provides an overview of the current status of new transplant modalities
Clinical Neuropathology Text and Color Atlas, 1st ed,
Demos Medical Publishing, LLC
This book provide a solid background in the structural alterations of common and less common but important nervous system diseases, along with their clinical manifestations. It incorporate into this background new information selected from the vast number of studies on molecular pathology and the pathogenesis of major nervous system diseases.
The book is divided into seventeen chapters with coverage of both non-neoplastic and neoplastic conditions of the female genital tract. All of the chapters are richly illustrated and contain numerous informational boxes and tables, which will provide the reader with practical information on all the aspects of a given entity.
A synthesis of the current knowledge about thalassaemia, taking stock of the field to see what has been achieved and what the future may hold. Includes historical background on the field, and coverage of the biology of the thalassaemias. Color and halftone illustrations. For clinicians and researchers.
This book introduces the reader to the concept of blood management and explains how to improve patient outcomes by avoiding undue blood loss, enhancing the patient’s own blood, effective management of anemia and coagulopathy.
This book focuses on the clinical and therapeutic implications of cancer stem cells. It include chapters concerning the basic science of both leukemic and solid tumor stem cell biology and a practical chapter on the isolation and characterization of cancer stem cells.
This textbook provides practical information on how to perform and interpret smears and use smears for diagnostic intraoperative neuropathology. The book covers most aspects of brain biopsies that require intraoperative or "frozen section" diagnosis, including tumors, non-neoplastic lesions, infectious diseases, and metastases to the brain.
Stem Cell Transplantation for Hematologic Malignancies.
ROBERT J. SOIFFER,
Humana Press Inc.
The first part of the book focuses on indications and results of transplantation for acute leukemias, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer, providing insight into the relative merits of transplant and nontransplant approaches to these disorders. Part II examines transplant-related complications including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver.
The main aim of this book is to provide a comprehensive source of information on all continuous human leukemia-lymphoma cell lines. The individual entries are designed to be succinct and to highlight the essential cell culture, clinical, immunological, genetic and functional features of the cell lines.
This book aims at providing the current knowledge in the area of molecular and cellular basis of breast cancer metastasis, biological factors that influence the metastatic process, developments in the diagnosis of metastatic breast cancer, and current thinking in the management of metastatic breast cancer.
Walter E. Finkbeiner, Richard L. Davis, Philip C. Ursell
The material is divided into two sections for ease of use: a manual covering specific autopsy procedures, biosafety, generation of autopsy reports, preparation of death certificates, and other essential subjects; and an atlas, organized by organ system, that captures the appearance of the complete spectrum of autopsy findings.
Barbara J. Bain, David M. Clark, Irvin A. Lampert.
Blackwell Science Ltd
Bone Marrow Pathology provides a comprehensive guide to the diagnosis of bone marrow disease. Combines all the techniques now applied to bone marrow diagnosis, including immunocytochemistry, flow-cytometery, immunohistochemistry and the diagnostic role of cytogenetic and molecular genetic analysis new link dOWNLOAd.
Leukaemia Diagnosis is a highly practical guide and reference source, which reflects the latest changes in the fields of morphology, cytochemistry, immunophenotyping, cytogenetics and molecular genetics.
This book summarizes the most current research on the anemia of chronic disease and identifies effective diagnostic strategies for this common clinical condition-covering key topics related to the design and selection of therapeutic options including the treatment of the underlying disease, the biology of erythropoietin and the regulation of erythropoiesis, the disturbance of iron homeostasis, and the complex nature of the systemic inflammatory response.
It provides a concise overview of the haemoglobinopathies and focuses on the selection, performance, and interpretation of relevant laboratory tests. The tests dealt with are mainly those done regularly in diagnostic haematology laboratories. Where more specialist tests are required, the reader is given an overview of what the specialist centre will do, with guidance on what the result will imply.